[Five cases of pseudomyxoma peritonei underwent abdominal lavage and administering CDDP].

Abstract

We examined five cases of pseudomyxoma peritonei with treatments of cytoreduction surgery, abdominal lavage and intraperiotoneal administration of cisplatin (CDDP). These primary lesions contained one case of pancreas and four cases of appendix. Histological types contained one case of well differentiated adenocarcinoma and four cases of signet ring cell carcinoma. All cases underwent a resection of primary lesion and muconodule, abdominal lavage with saline and 5% glucose or low molecule dextran solution. CDDP was administered into the abdominal space during and after the surgery, a total amount of 100 to 400 mg/body. There were no cases of collected ascites within one year, except one case that we could not follow. There was a possibility that a short-term quality of life was improved by multidiciplinary therapy containing cytoreduction surgery and intraperiotoneal administration of CDDP.

• Authors: Norimichi Okada, Kichiro Ishibashi, Hiroshi Nakada, Tatsuya Miyazaki, Jun Sobajima, Tsuyoshi Gonda, Hideyuki Ishida
• Journal: Gan to kagaku ryoho. Cancer & chemotherapy (Gan To Kagaku Ryoho) Vol. 34 Issue 12 Pg. 1955-7 (Nov 2007) ISSN: 0385-0684 [Print] Japan
• PMID: 18219863 (Publication Type: Case Reports, English Abstract, Journal Article)

Chemical References

• Cisplatin

Topics

• Adult
• Aged
• Cisplatin (administration & dosage, therapeutic use)
• Dose-Response Relationship, Drug
• Female
• Humans
• Male
• Middle Aged
• Peritoneal Lavage
• Prognosis
• Pseudomyxoma Peritonei (drug therapy, pathology, surgery)