Changes in the structure and functions of membranes in erythrocytes and Ehrlich ascites carcinoma cells under the influence of a new generation hybrid antioxidant IKhFAN-10.

Abstract

We studied the effect of a new generation hybrid antioxidant IKhFAN-10 on the structure and function of cell membranes (organization of the lipid bilayer and proteins and activity of ion channels). The test preparation proposed for the therapy of neurodegenerative diseases modified properties of membranes in erythrocytes and Ehrlich ascites carcinoma cells and affected functional activity of cells. We determined the doses of this antioxidant, which did not cause side effects.

• Authors: O M Vekshina, L D Fatkullina, Yu A Kim, E B Burlakova
• Journal: Bulletin of experimental biology and medicine (Bull Exp Biol Med) Vol. 143 Issue 4 Pg. 426-30 (Apr 2007) ISSN: 0007-4888 [Print] United States
• PMID: 18214291 (Publication Type: Journal Article)

Chemical References

• Antioxidants
• Flavonoids
• IKhFAN-10
• Potassium Channels
• Potassium

Topics

• Animals
• Antioxidants (chemistry, pharmacology)
• Carcinoma, Ehrlich Tumor (metabolism, pathology)
• Cell Line, Tumor
• Dose-Response Relationship, Drug
• Erythrocyte Membrane (drug effects, metabolism)
• Erythrocytes (cytology, drug effects, metabolism)
• Flavonoids (chemistry, pharmacology)
• Membrane Fluidity (drug effects)
• Potassium (metabolism)
• Potassium Channels (drug effects, metabolism)
• Rats
• Temperature
• Time Factors