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Four cardiac hormones eliminate up to two-thirds of human breast cancers in athymic mice.

AbstractBACKGROUND:
Four cardiac hormones i.e. atrial natriuretic peptide (ANP), vessel dilator, long acting natriuretic peptide (LANP) and kaliuretic peptide have anticancer effects in vitro.
MATERIALS AND METHODS:
These four cardiac hormones were infused subcutaneously for 28 days with weekly fresh hormones at 3 nM min(-1) kg(-1) body weight in athymic mice bearing human breast adenocarcinomas.
RESULTS:
Vessel dilator, LANP, kaliuretic peptide and ANP eliminated 67%, 50%, 67% and 33% of the HTB-132 human breast adenocarcinomas. LANP eliminated 100% and vessel dilator 1/3 of CRL-2327 breast adenocarcinomas. There was no recurrence of the breast cancers in the primary site and no metastasis except in the ANP-treated group in one year post-treatment. The natriuretic peptide receptors-A and -C were decreased 50% and 31%, respectively, in metastatic versus primary ANP-treated breast adenocarcinomas.
CONCLUSION:
Four cardiac hormones eliminate up to two-thirds of human breast adenocarcinomas in athymic mice.
AuthorsDavid L Vesely, Brian A Vesely, Ehrentraud J Eichelbaum, Ying Sun, Abdel A Alli, William R Gower Jr
JournalIn vivo (Athens, Greece) (In Vivo) 2007 Nov-Dec Vol. 21 Issue 6 Pg. 973-8 ISSN: 0258-851X [Print] Greece
PMID18210743 (Publication Type: Journal Article, Research Support, U.S. Gov't, Non-P.H.S.)
Chemical References
  • Antineoplastic Agents
  • Peptide Fragments
  • Protein Precursors
  • atrial natriuretic factor precursor (79-98)
  • atrial natriuretic factor prohormone (31-67)
  • Atrial Natriuretic Factor
Topics
  • Adenocarcinoma (drug therapy, pathology)
  • Animals
  • Antineoplastic Agents (therapeutic use)
  • Atrial Natriuretic Factor (therapeutic use)
  • Breast Neoplasms (drug therapy, pathology)
  • Cell Line, Tumor
  • Humans
  • Mice
  • Neoplasm Metastasis
  • Peptide Fragments (therapeutic use)
  • Protein Precursors (therapeutic use)

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