Fructose-induced breath hydrogen in patients with fruit intolerance.

Abstract

GOALS:

To measure bloating score, flatus passage, and hydrogen production after oral fructose in patients with history of fruit intolerance and compare these parameters with those in normal controls.

BACKGROUND:

Some patients complain of abdominal distention and excessive flatus after ingesting certain fruits such as mango, persimmon, and grapes but not after eating apricots and melon.

STUDY:

We recorded breath hydrogen, flatus passage and bloating after 20 g fructose in 8 patients with history of fruit intolerance and 4 healthy controls. Breath hydrogen was measured every 15 minutes for 480 minutes using EC-60 gastrolyzer. Number of passage of flatus was recorded over 8 hours. Severity of abdominal distention on a scale of 1 to 10 was noted.

RESULTS:

The patients with fruit intolerance produced breath hydrogen 1745.2+/-7.8 parts per million, passed flatus 13.8+/-0.3 times, and had bloating score of 5.7+/-0.1. The healthy controls produced breath hydrogen 712.5+/-5.8 parts per million in 8 hours, passed flatus 7.2+/-0.5 time, and had bloating score of 2.7+/-0.2.

CONCLUSIONS:

After 20 g fructose, patients with history of fruit intolerance produce more breath hydrogen, pass flatus more frequently, and have a higher bloating score compared with healthy controls.

• Authors: Nirmal S Mann, Eddie C Cheung
• Journal: Journal of clinical gastroenterology (J Clin Gastroenterol) Vol. 42 Issue 2 Pg. 157-9 (Feb 2008) ISSN: 0192-0790 [Print] United States
• PMID: 18209585 (Publication Type: Journal Article)

Chemical References

• Fructose
• Hydrogen

Topics

• Adult
• Aged
• Breath Tests (methods)
• Dyspepsia (etiology, physiopathology)
• Female
• Flatulence (etiology)
• Fructose (metabolism)
• Fruit (adverse effects, metabolism)
• Humans
• Hydrogen (metabolism)
• Male
• Middle Aged
• Severity of Illness Index