HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Frequency and characteristics of TBII-seronegative patients in a population with untreated Graves' hyperthyroidism: a prospective study.

AbstractOBJECTIVE:
It is claimed that second generation thyrotropin-binding inhibitory immunoglobulin (TBII) assays have a very high sensitivity for the diagnosis of Graves' hyperthyroidism (GH). However, studies evaluating the accuracy of TBII have been retrospective in nature and/or GH had not been diagnosed independently of TBII. The aim of the present study, therefore, was to prospectively evaluate the frequency and characteristics of TBII-seronegative patients in a population of untreated GH diagnosed independent of serum TBII.
DESIGN:
Prospective multicentre observational study.
PATIENTS:
A total of 259 consecutive untreated patients with a first episode of GH, diagnosed independent of serum TBII. TBII levels were measured by second generation assay and correlated to thyroid function, clinical characteristics and exposure to environmental factors.
RESULTS:
Serum TBII was positive in 245 (94.6%) patients and negative (< 2 IU/l) in 14 (5.4%) patients. TBII-seronegative patients had lower fT4 (median 42.5 vs. 53.9 pmol/l, P = 0.02), T3 (median 3.55 vs. 4.90 nmol/l, P < 0.01) and fT3-index (median 4.30 vs. 6.27, P < 0.01) compared to TBII-seropositive patients. None of the TBII-seronegative patients had TSH-receptor activating mutations, Graves' orbitopathy or pretibial myxedema. Serum TBII was positively correlated to free T3 (fT3)-index and free T4 (fT4)-index (P < 0.01), goitre size (P < 0.01) and the prevalence of Graves' orbitopathy (P < 0.01). There were no significant differences between TBII-seropositive and TBII-seronegative patients in environmental factors.
CONCLUSION:
The prevalence of TBII-seronegativity in untreated patients with GH is 5.4% using a second generation assay. TBII-seronegative patients have biochemically less severe thyrotoxicosis and no Graves' orbitopathy. TBII-seronegative and TBII-seropositive patients apparently belong to the same population of GH, albeit the severity of the autoimmune attack is less in TBII-seronegative patients.
AuthorsXander G Vos, Natalie Smit, Erik Endert, Jan G P Tijssen, Wilmar M Wiersinga
JournalClinical endocrinology (Clin Endocrinol (Oxf)) Vol. 69 Issue 2 Pg. 311-7 (Aug 2008) ISSN: 1365-2265 [Electronic] England
PMID18208575 (Publication Type: Journal Article, Multicenter Study)
Chemical References
  • Immunoglobulins, Thyroid-Stimulating
  • Thyroid Hormones
  • thyrotropin-binding inhibitory immunoglobulin
Topics
  • Adult
  • Female
  • Graves Disease (blood, diagnosis, epidemiology, immunology)
  • Humans
  • Hyperthyroidism (blood, diagnosis, epidemiology, immunology)
  • Immunoglobulins, Thyroid-Stimulating (analysis, blood)
  • Male
  • Middle Aged
  • Seroepidemiologic Studies
  • Thyroid Hormones (blood)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: