HOMEPRODUCTSSERVICESCOMPANYCONTACTFAQResearchDictionaryPharmaMobileSign Up FREE or Login

Inhibitory property of the Piper betel phenolics against photosensitization-induced biological damages.

Abstract
The Piper betel phenolics, allylpyrocatechol (APC) and chavibetol (CHV), were found to protect photosensitization-mediated lipid peroxidation (LPO) of rat liver mitochondria effectively, APC being significantly more potent. The better activity of APC vis-à-vis CHV could be attributed to its higher reactivity with (1)O(2), as revealed from the rate constant values of (1)O(2) quenching by the respective phenolics. APC also prevented the detrimental effects of the Type II photosensitization-induced toxicity to mouse fibroblast L929 cells. The results suggest that APC may play an important role in protecting biological systems against damage, by eliminating (1)O(2) generated from certain endogenous photosensitizers.
AuthorsSoumyaditya Mula, Debashish Banerjee, Birija S Patro, Sayanti Bhattacharya, Atanu Barik, Sandip K Bandyopadhyay, Subrata Chattopadhyay
JournalBioorganic & medicinal chemistry (Bioorg Med Chem) Vol. 16 Issue 6 Pg. 2932-8 (Mar 15 2008) ISSN: 1464-3391 [Electronic] England
PMID18207412 (Publication Type: Journal Article)
Chemical References
  • Antioxidants
  • Phenols
  • Photosensitizing Agents
  • Plant Extracts
  • Radiation-Protective Agents
  • Oxygen
Topics
  • Animals
  • Antioxidants
  • Lipid Peroxidation (drug effects)
  • Mice
  • Mitochondria, Liver (metabolism)
  • Oxygen
  • Phenols (pharmacology)
  • Photosensitizing Agents (adverse effects)
  • Piper betle (chemistry)
  • Plant Extracts
  • Radiation-Protective Agents (pharmacology)
  • Rats

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research network!


Choose Username:
Email:
Password:
Verify Password: