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A unique therapeutic approach to emesis and itch with a proanthocyanidin-rich genonutrient.

AbstractBACKGROUND:
We examined the therapeutic potential of a proprietary Croton palanostigma extract (Zangrado(R)) in the management of emesis and itch.
METHODS:
Emesis was induced in ferrets with morphine-6-glucuronide (0.05 mg/kg sc) in the presence of Zangrado (3 mg/kg, ip) and the cannabinoid receptor 1 antagonist, AM 251 (5 mg/kg, ip). Topical Zangrado (1%) was assessed for anti-pruretic actions in the 5-HT-induced scratching model in rats and evaluated in capsaicin-induced gastric hyperemia as measured by laser doppler flow. In the ApcMinmouse model of precancerous adenomatosis polyposis, mice received Zangrado (100 mug/ml in drinking water) from the age of 6 - 16 weeks for effects on polyp number. In RAW 264.7 cells Zangrado was examined for effects on lipopolysaccharide-induced nitrite production.
RESULTS:
Zangrado was a highly effective anti-emetic, reducing morphine-induced vomiting and retching by 77%. These benefits were not associated with sedation or hypothermia and were not reversed by cannabinoid receptor antagonism. Itch responses were blocked in both the morphine and 5-HT models. Zangrado did not exacerbate the ApcMincondition rather health was improved. Capsaicin-induced hyperemia was blocked by Zangrado, which also attenuated the production of nitric oxide by activated macrophages.
CONCLUSION:
Zangrado is an effective anti-emetic and anti-itch therapy that is devoid of common side-effects, cannabinoid-independent and broadly suppresses sensory afferent nerve activation. This complementary medicine represents a promising new approach to the management of nausea, itch and irritable bowel syndrome.
AuthorsMark J S Miller, Brian K Reuter, John L Wallace, Keith A Sharkey
JournalJournal of translational medicine (J Transl Med) Vol. 6 Pg. 3 (Jan 18 2008) ISSN: 1479-5876 [Electronic] England
PMID18205911 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Antiemetics
  • Antipruritics
  • Morphine Derivatives
  • Piperidines
  • Plant Extracts
  • Proanthocyanidins
  • Pyrazoles
  • Receptor, Cannabinoid, CB1
  • proanthocyanidin
  • AM 251
  • morphine-6-glucuronide
Topics
  • Animals
  • Antiemetics (therapeutic use)
  • Antipruritics (therapeutic use)
  • Cell Line
  • Croton
  • Ferrets
  • Male
  • Mice
  • Mice, Inbred C57BL
  • Morphine Derivatives (administration & dosage)
  • Nausea (drug therapy)
  • Piperidines
  • Plant Extracts (therapeutic use)
  • Proanthocyanidins (therapeutic use)
  • Pruritus (chemically induced, drug therapy)
  • Pyrazoles
  • Rats
  • Rats, Sprague-Dawley
  • Receptor, Cannabinoid, CB1 (antagonists & inhibitors)
  • Vomiting (chemically induced, drug therapy)

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