1-year follow-up of autologous muscle-derived stem cell injection pilot study to treat stress urinary incontinence.

Abstract

We hereby report a 1-year follow-up on eight women in the first North America trial in which stress urinary incontinence (SUI) was treated with muscle-derived stem cell injections. Mean and median follow-up in this group was 16.5 and 17 months (range 3-24 months). Improvement in SUI was seen in five of eight women, with one achieving total continence. Onset of improvement was between 3 and 8 months after injection. Cure or improvement continued at a median of 10 months. No serious adverse events were reported.

• Authors: L K Carr, D Steele, S Steele, D Wagner, R Pruchnic, R Jankowski, J Erickson, J Huard, M B Chancellor
• Journal: International urogynecology journal and pelvic floor dysfunction (Int Urogynecol J Pelvic Floor Dysfunct) Vol. 19 Issue 6 Pg. 881-3 (Jun 2008) England
• PMID: 18204978 (Publication Type: Clinical Trial, Journal Article, Research Support, Non-U.S. Gov't)

Topics

• Adult
• Aged
• Feasibility Studies
• Female
• Humans
• Middle Aged
• Myoblasts (transplantation)
• Pilot Projects
• Stem Cell Transplantation
• Transplantation, Autologous
• Urinary Incontinence, Stress (therapy)