Abstract | OBJECTIVE: METHODS AND RESULTS: Study sample 1 consisted of 3657 patients with myocardial infarction and 1211 control individuals and sample 2 comprised 1392 patients and 1392 controls. Haplotypes were inferred from genotype analyses of tagging single nucleotide polymorphisms dispersed among the fibrinogen genes. The frequencies of these haplotypes were not significantly different between the case and control groups in either sample (P > or = 0.07). In addition, haplotypes specific for individual fibrinogen genes were analyzed. No substantial differences in the frequencies of these haplotypes were observed between the groups (P > or = 0.13). Finally, haplotypes composed of SNPs that exhibited relatively low pairwise allelic associations among each other were examined. The proportions of the haplotypes were not significantly different between cases and controls (P > or = 0.12). CONCLUSIONS:
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Authors | Werner Koch, Petra Hoppmann, Janita Biele, Jakob C Mueller, Albert Schömig, Adnan Kastrati |
Journal | Arteriosclerosis, thrombosis, and vascular biology
(Arterioscler Thromb Vasc Biol)
Vol. 28
Issue 4
Pg. 758-63
(Apr 2008)
ISSN: 1524-4636 [Electronic] United States |
PMID | 18202324
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
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Topics |
- Aged
- Alleles
- Case-Control Studies
- Female
- Fibrinogen
(genetics)
- Gene Frequency
- Genetic Variation
- Haplotypes
- Humans
- Linkage Disequilibrium
- Male
- Middle Aged
- Myocardial Infarction
(blood, etiology, genetics)
- Polymorphism, Single Nucleotide
- Risk Factors
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