Abstract | BACKGROUND: PATIENTS AND METHODS:
Formalin-fixed and paraffin-embedded samples from 20 DFs and 20 DFSPs were stained immunohistochemically with antibodies directed against COX-2. Staining was evaluated semiquantitatively for percentage and intensity using a three-tiered system. DFs were graded and analyzed by cellularity. Findings within the tumors were compared with fibrocyte staining in adjacent tissue. The results were analyzed. RESULTS: Nineteen DFs (95%) and 15 DFSPs (75%) were immunopositive for COX-2; this difference was not statistically significant. Highly cellular DFs showed more widespread (p = 0.0039; r = 0.614) and more intense (p = 0.0586; r = 0.429) staining than less cellular DFs and more prominent staining in adjacent fibroblasts (p = 0.044; r = 0.608). CONCLUSIONS: COX-2 immunostaining does not distinguish DFs from DFSPs. However, the enzyme is expressed more widely and more intensely in more cellular, possibly younger, DFs. The prominent expression of COX-2 in DFSP may have clinical implications for treatment with COX-2 inhibitors in tumors that are not amenable to surgery.
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Authors | Neta Adler, Cochava Tsabari, Jaqueline Sulkes, Dean Ad-El, Meora Feinmesser |
Journal | Journal of cutaneous pathology
(J Cutan Pathol)
Vol. 35
Issue 6
Pg. 532-5
(Jun 2008)
ISSN: 1600-0560 [Electronic] United States |
PMID | 18201240
(Publication Type: Comparative Study, Journal Article)
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Chemical References |
- Biomarkers, Tumor
- Cyclooxygenase 2
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Topics |
- Biomarkers, Tumor
(analysis, metabolism)
- Cyclooxygenase 2
(analysis, metabolism)
- Dermatofibrosarcoma
(diagnosis, enzymology)
- Diagnosis, Differential
- Fluorescent Antibody Technique, Indirect
- Histiocytoma, Benign Fibrous
(diagnosis, enzymology)
- Humans
- Skin Neoplasms
(diagnosis, enzymology)
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