| Abstract | AIM: To study whether immunogenecity of tumor cells may be altered upon the development of cytostatic drug resistance and what is the efficacy of vaccines prepared from such tumor cells. METHODS: Using immunological methods, the influence of vaccines prepared from Lewis lung carcinoma (LLC) cells, sensitive or resistant to cisplatin, with the use of cytotoxic lectins of B. subtilis B-7025 on the course of tumor development and the main effector reactions of antitumor resistance has been studied. RESULTS: The vaccine prepared from the cells of chemoresistant LLC and lectines of B. subtilis B-7025 possesses antitumor activity, what is evidenced by the indexes of tumor growth inhibition and increased activity of effector cells of antitumor immunity. CONCLUSIONS: The antitumor action of vaccines prepared with the use of chemoresistant tumor cells is differing is more pronounced, than in the case of chemosensitive variant. |
| Authors | G Potebnya, N Cheremshenko, G Lisovenko, I Voyekova, V Bazas', I Todor, V Chekhun
(Affiliation: RE Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology NAS of Ukraine, Kiev, Ukraine. iris at onconet.kiev.ua)
|
| Journal | Experimental oncology
(Exp Oncol)
Vol. 29
Issue 4
Pg. 277-80
(Dec 2007)
ISSN: 1812-9269 Ukraine |
| PMID | 18199983
(Publication Type: Journal Article)
|
| Chemical References |
- Antineoplastic Agents
- Cancer Vaccines
- Lectins
- Cisplatin
|
| Topics |
- Animals
- Antineoplastic Agents
(pharmacology)
- Bacillus subtilis
(chemistry)
- Cancer Vaccines
(therapeutic use)
- Carcinoma, Lewis Lung
(therapy)
- Cisplatin
(pharmacology)
- Drug Resistance, Neoplasm
- Lectins
(therapeutic use)
- Male
- Mice
|
