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[The proper use of quinolones to the elderly patient with community-acquired pneumonia examined by Monte Carlo simulation].

Abstract
Recently, proper use of antimicrobial agents for treatment of infections based on pharmacokinetics (PK)/ pharmacodynamics (PD) theory has been recommended to many clinical doctors. To consider the optimized administration method based on PK/PD theory for the elderly patients of gatifloxacin (GFLX), which was one of the oral respiratory quinolone antibacterial, Monte Carlo Simulation was conducted with community-acquired pneumonia and susceptibility data for Streptococcus pneumoniae (345 strains) collected by the second gatifloxacin surveillance study. From this results, the probabilities of achieving AUC/MIC 30 against pneumococcus for the elderly patients was 96.3% at twice-daily dosing of GFLX 100 mg, 97.2% at twice-daily dosing of GFLX 200 mg, therefore, it was suggested that the clinical effectiveness of the regimen of GFLX 100 mg was as well as the regimen of GFLX 200 mg.
AuthorsKatsunori Yanagihara, Yoshitomo Morinaga, Kazuko Fukushima, Shigeki Nakamura, Shintaro Kurihara, Masafumi Seki, Kouichi Izumikawa, Hiroshi Kakeya, Yoshihiro Yamamoto, Yoshitsugu Miyazaki, Yoichi Hirakata, Takayoshi Tashiro, Shigeru Kohno
JournalThe Japanese journal of antibiotics (Jpn J Antibiot) Vol. 60 Issue 5 Pg. 251-6 (Oct 2007) ISSN: 0368-2781 [Print] Japan
PMID18198653 (Publication Type: English Abstract, Journal Article)
Chemical References
  • Anti-Infective Agents
  • Fluoroquinolones
  • gatifloxacin
Topics
  • Aged
  • Anti-Infective Agents (administration & dosage, pharmacokinetics)
  • Community-Acquired Infections (drug therapy)
  • Fluoroquinolones (administration & dosage, pharmacokinetics)
  • Humans
  • Middle Aged
  • Monte Carlo Method
  • Pneumonia (drug therapy)

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