Effects of decylubiquinone (coenzyme Q10 analog) supplementation on SHRSP.

Abstract

Decylubiquinone treatment in vitro has demonstrated a potent inhibitor effect on reactive oxidative species production. However, the effectin vivo has not been demonstrated yet. Thus, rats SHRSP male were divided in two groups: treated and controls (n=6, each). The treated group received 10 mg/Kg(-)/body weight of decylubiquinone diluted in coconut oil by oral gavage during four weeks. Control rats just received the vehicle. Body weight, diuresis, food and water intake, systolic blood pressure, total cholesterol, LDL-cholesterol, HDL-cholesterol, triglycerides, blood glucose levels and malondialdehyde were determined. There were a significant (p<0.05) reduction on systolic blood pressure, plasma malondialdehyde, total cholesterol and LDL-cholesterol in the treated group. Additionally, HDL-cholesterol also increased significantly. However, body weight, diuresis, food and water intake, blood glucose levels and triglycerides did not alter after treatment. Thus, decylubiquinone can be a new antihypertensive, hypolipidemic and antioxidant agent on the prevention and treatment of diseases linked to oxidative stress.

• Authors: Leonardo Borges Murad, Marcela Rodrigues Moreira Guimarães, Lucia Marques Vianna
• Journal: BioFactors (Oxford, England) (Biofactors) Vol. 30 Issue 1 Pg. 13-8 ( 2007) ISSN: 0951-6433 [Print] Netherlands
• PMID: 18198397 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antihypertensive Agents
• Antioxidants
• Blood Glucose
• Hypolipidemic Agents
• Lipids
• Ubiquinone
• Malondialdehyde
• 2,3-dimethoxy-5-methyl-6-decyl-1,4-benzoquinone

Topics

• Animals
• Antihypertensive Agents (pharmacology)
• Antioxidants (pharmacology)
• Blood Glucose (drug effects)
• Blood Pressure (drug effects)
• Disease Models, Animal
• Hypolipidemic Agents (pharmacology)
• Lipids (blood)
• Male
• Malondialdehyde (blood)
• Oxidative Stress (drug effects)
• Rats
• Rats, Inbred SHR
• Ubiquinone (analogs & derivatives, pharmacology)