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Donepezil improves obstructive sleep apnea in Alzheimer disease: a double-blind, placebo-controlled study.

AbstractBACKGROUND:
There is an association between Alzheimer disease and sleep-disordered breathing. Donepezil is the drug most frequently used to treat cognitive symptoms in Alzheimer disease. This study evaluates the effects of donepezil on obstructive sleep apnea in patients with Alzheimer disease.
METHODS:
Randomized, double-blind, placebo-controlled design. Twenty-three patients with mild-to-moderate Alzheimer disease and apnea-hypopnea index (AHI) > 5/h were allocated to two groups: donepezil treated (n = 11) and placebo treated (n = 12). Polysomnography and cognitive evaluation using Alzheimer disease assessment scale-cognitive (ADAS-cog) subscale were performed at baseline and after 3 months. Cognitive and sleep data were analyzed using analysis of variance.
RESULTS:
AHI and oxygen saturation improved significantly after donepezil treatment compared to baseline and placebo (p < 0.05). Rapid eye movement (REM) sleep duration increased after donepezil treatment (p < 0.05). ADAS-cog scores improved after donepezil treatment, although they did not correlate with REM sleep increase and sleep apnea improvement (p < 0.01).
CONCLUSIONS:
Donepezil treatment improved AHI and oxygen saturation in patients with Alzheimer disease. Treatment also increased REM sleep duration and reduced ADAS-cog scores.
TRIAL REGISTRATION:
ClinicalTrials.gov Identifier: NCT00480870.
AuthorsWalter Moraes, Dalva Poyares, Lucia Sukys-Claudino, Christian Guilleminault, Sergio Tufik
JournalChest (Chest) Vol. 133 Issue 3 Pg. 677-83 (Mar 2008) ISSN: 0012-3692 [Print] United States
PMID18198262 (Publication Type: Comparative Study, Journal Article, Multicenter Study, Randomized Controlled Trial)
Chemical References
  • Indans
  • Nootropic Agents
  • Piperidines
  • Donepezil
Topics
  • Aged
  • Aged, 80 and over
  • Alzheimer Disease (complications, drug therapy, psychology)
  • Donepezil
  • Double-Blind Method
  • Female
  • Follow-Up Studies
  • Humans
  • Indans (therapeutic use)
  • Male
  • Middle Aged
  • Nootropic Agents (therapeutic use)
  • Piperidines (therapeutic use)
  • Polysomnography
  • Psychometrics (methods)
  • Sleep Apnea, Obstructive (complications, drug therapy, physiopathology)
  • Sleep, REM (physiology)
  • Treatment Outcome

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