Phospholipid-induced modifications in the brain of animals fed with cholesterol-supplemented diet.

Abstract

1) Cholesterol - enriched diet induces changes in the phospholipid fatty acids of particulate fractions and modifications in the membrane-bound enzyme: 2) BC-PL (100 mg/kg i.p., as shown in rabbits) prevent cholesterol-induced modifications at brain level: 3)BC-PL (100 mg/kg i.v., as shown in mice) have a recovery effect on the cholesterol-induced modification at brain level; 4) It is suggested that some atherosclerotic lesions are analogous to those reproduced by anoxia; 5) It is suggested that the effect of BC-PL is a direct action at the level of the brain cellular membranes.

• Authors: G Toffano, P Gonzato, D Benvegnù
• Journal: Advances in experimental medicine and biology (Adv Exp Med Biol) Vol. 72 Pg. 293-306 ( 1976) ISSN: 0065-2598 [Print] United States
• PMID: 181962 (Publication Type: Journal Article, Review)

Chemical References

• Cholesterol, Dietary
• Phospholipids
• Cholesterol
• Sodium
• Cyclic AMP
• Adenosine Triphosphatases
• Magnesium
• Potassium

Topics

• Adenosine Triphosphatases (metabolism)
• Animals
• Arteriosclerosis (prevention & control)
• Behavior, Animal (drug effects)
• Body Weight
• Brain (drug effects, enzymology, metabolism)
• Cell Membrane (drug effects, enzymology)
• Cholesterol (blood, pharmacology)
• Cholesterol, Dietary
• Cyclic AMP (metabolism)
• Diet, Atherogenic
• Enzyme Activation (drug effects)
• Liver (metabolism)
• Magnesium (pharmacology)
• Mice
• Organ Size
• Phospholipids (pharmacology)
• Potassium (pharmacology)
• Rabbits
• Sodium (pharmacology)