[Effect of nizofenone on the symptomatic vasospasm after aneurysmal subarachnoid hemorrhage and its relationship to the levels of serum complements (CH50, C3 and C4)].

Abstract

Serum complements (CH50, C3 and C4) after aneurysmal subarachnoid hemorrhage were measured in 42 patients over 2 to 3-week period. Nizofenone, an anti-vasospasmotic agent, was administered to 11 patients. In the nizofenone-treated group, 8 patients showed decreased serum C4 levels 5 days after the onset of subarachnoid hemorrhage, but among them, only 2 patients showed symptomatic vasospasm. Considering our previous data (majority of patients who showed decreased serum C4 levels presented with symptomatic vasospasm), these results suggest a favorable effect of nizofenone on the symptomatic vasospasm after aneurysmal subarachnoid hemorrhage.

• Authors: N Ogata, Y Yonekawa, T Kawano, T Tsukahara
• Journal: Nihon geka hokan. Archiv fur japanische Chirurgie (Nihon Geka Hokan) Vol. 60 Issue 2 Pg. 135-9 (Mar 01 1991) ISSN: 0003-9152 [Print] Japan
• PMID: 1819244 (Publication Type: English Abstract, Journal Article)

Chemical References

• Complement C3
• Complement C4
• Imidazoles
• nizofenone

Topics

• Adult
• Aged
• Aged, 80 and over
• Complement Activation
• Complement C3 (metabolism)
• Complement C4 (metabolism)
• Complement Hemolytic Activity Assay
• Drug Evaluation
• Female
• Humans
• Imidazoles (therapeutic use)
• Intracranial Aneurysm (complications, immunology)
• Ischemic Attack, Transient (drug therapy, etiology)
• Male
• Middle Aged
• Rupture, Spontaneous
• Subarachnoid Hemorrhage (complications, immunology)