Expression of PINCH protein in gliomas and its clinicopathological significance.

Abstract

OBJECTIVES:

Particularly interesting new cysteine-histidine-rich protein (PINCH), as a LIM domain adapter protein, functions in the integrin and growth factor signal transduction pathway, and is upregulated in tumor-associated stroma in several types of cancers. However, no study of PINCH has been carried out in gliomas, therefore we examined PINCH expression in gliomas and its clinicopathological significance.

METHODS:

PINCH expression was immunohistochemically examined in 82 gliomas, along with 26 matched adjacent normal brain samples and 10 recurred gliomas.

RESULTS:

PINCH was strongly expressed in the primary (35%, p = 0.0001) or recurred tumors (40%, p = 0.004) and weak in normal brain tissue. PINCH expression was significantly increased in high-grade gliomas (55 vs. 24%, high- vs. low-grade gliomas, p = 0.004). There was no association of PINCH expression with gender, age, tumor number, size, histological type and tumor location (p > 0.05).

CONCLUSIONS:

PINCH expression may be involved in glioma development and differentiation.

• Authors: Ming-Wei Wang, Ping Gu, Zhi-Yong Zhang, Zhen-Long Zhu, Yan-Min Li, Hui-Xin Zhao, Xiao-Feng Sun
• Journal: Oncology (Oncology) Vol. 72 Issue 5-6 Pg. 343-6 ( 2007) ISSN: 1423-0232 [Electronic] Switzerland
• PMID: 18187956 (Publication Type: Journal Article)
• Copyright: (c) 2008 S. Karger AG, Basel

Chemical References

• Adaptor Proteins, Signal Transducing
• Biomarkers, Tumor
• DNA-Binding Proteins
• LIM Domain Proteins
• LIMS1 protein, human
• Membrane Proteins

Topics

• Adaptor Proteins, Signal Transducing
• Adolescent
• Adult
• Aged
• Biomarkers, Tumor (biosynthesis)
• Brain (metabolism)
• Brain Neoplasms (metabolism)
• Child
• Child, Preschool
• DNA-Binding Proteins (biosynthesis)
• Female
• Glioma (metabolism)
• Humans
• LIM Domain Proteins
• Male
• Membrane Proteins
• Middle Aged
• Neoplasm Recurrence, Local (metabolism)