Abstract | OBJECTIVES: METHODS: A total of 219 patients with primary bone tumors entered the study. The patients were divided into 2 groups according to their age, including a teenage (10-19 years old) and an adult group (> or =20 years old). In each group, the patients were divided into several subgroups ( osteosarcoma, benign bone tumors or tumor-like lesions, giant cell tumor, and other primary malignant bone tumors). An age- and gender-matched control population was also studied in each group. Blood samples were taken for measurement of serum BALP, N-MID and CTX. RESULTS: The serum BALP levels in patients with osteosarcoma were significantly higher than those of patients in the other subgroups and the controls, both in the teenage (p = 0.01) and the adult group (p = 0.000). The serum N-MID and CTX levels did not significantly differ among patients of different subgroups and the controls, both in the teenage (p = 0.773 and p = 0.747, respectively) and the adult group (p = 0.163 and p = 0.074, respectively). CONCLUSIONS: A high serum BALP level is valuable for the diagnosis of adult osteosarcoma, but its use in the development of a differential diagnosis in the teenage patients is not advised because serum BALP levels are also affected by age, pubertal stage and growth velocity. Both serum N-MID and serum CTX are hardly useful in the differential diagnosis of primary bone tumors.
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Authors | Jingsheng Wang, Fuxing Pei, Chongqi Tu, Huaixian Zhang, Xueyong Qiu |
Journal | Oncology
(Oncology)
Vol. 72
Issue 5-6
Pg. 338-42
( 2007)
ISSN: 1423-0232 [Electronic] Switzerland |
PMID | 18187955
(Publication Type: Journal Article)
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Copyright | (c) 2008 S. Karger AG, Basel |
Chemical References |
- Biomarkers
- Biomarkers, Tumor
- Collagen Type I
- Osteocalcin
- Alkaline Phosphatase
|
Topics |
- Adolescent
- Adult
- Alkaline Phosphatase
(blood)
- Biomarkers
(blood)
- Biomarkers, Tumor
(blood)
- Bone Neoplasms
(blood, metabolism)
- Child
- Collagen Type I
(blood)
- Female
- Humans
- Male
- Osteocalcin
(blood)
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