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Human umbilical cord blood-derived CD34+ cells can be used as a prophylactic agent for experimental heatstroke.

Abstract
We attempted to assess the prophylactic effect of human umbilical cord blood-derived CD34(+) cells in experimental heatstroke. Anesthetized rats, 1 day before heat stress, were divided into 2 major groups and given CD34(-) cells (defined by 1 x 10(6) human cord blood lymphocytes and monocytes that contained <0.2% CD34(+) cells) or CD34(+) cells (defined by 1 x 10(6) human cord blood lymphocytes and monocytes that contained >95% CD34(+) cells). They were exposed to ambient temperature of 43 degrees C for 70 min to induce heatstroke. When the CD34(-) cells-treated or untreated rats underwent heat stress, their survival time values were found to be 20-24 min. Pretreatment with CD34(+) cells significantly increased survival time (123-351 min). As compared with normothermic controls, all CD34(-) cells-treated heatstroke animals displayed hypotension, hepatic and renal failure, hypercoagulable state, activated inflammation, and cerebral ischemia and injury. However, these heatstroke reactions all were significantly suppressed by CD34(+) cells pretreatment. In addition, the levels of interleukin-10 in plasma and glial cell line-derived neurotrophic factors in brain were all significantly increased after CD34(+) cell administration during heatstroke. Our data indicate that human umbilical cord-derived CD34(+) cells can be used as a prophylactic agent for experimental heatstroke.
AuthorsWei-Shou Hwang, Sheng-Hsien Chen, Cheng-Hsien Lin, Hsiu-Kang Chang, Wei-Chun Chen, Mao-Tsun Lin
JournalJournal of pharmacological sciences (J Pharmacol Sci) Vol. 106 Issue 1 Pg. 46-55 (Jan 2008) ISSN: 1347-8613 [Print] Japan
PMID18187924 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Antigens, CD34
  • Glial Cell Line-Derived Neurotrophic Factor
  • Nitrates
  • Nitrites
  • Tumor Necrosis Factor-alpha
  • Interleukin-10
Topics
  • Animals
  • Antigens, CD34 (analysis)
  • Basal Ganglia (metabolism)
  • Cerebrovascular Disorders (etiology, prevention & control)
  • Cord Blood Stem Cell Transplantation
  • Disease Models, Animal
  • Fetal Blood (cytology)
  • Glial Cell Line-Derived Neurotrophic Factor (metabolism)
  • Heat Stroke (complications, metabolism, prevention & control)
  • Humans
  • Interleukin-10 (blood)
  • Kidney Diseases (etiology, prevention & control)
  • Liver Diseases (etiology, prevention & control)
  • Male
  • Multiple Organ Failure (etiology, metabolism, prevention & control)
  • Nerve Degeneration (etiology, prevention & control)
  • Nitrates (blood)
  • Nitrites (blood)
  • Rats
  • Rats, Sprague-Dawley
  • Stem Cells (immunology, metabolism)
  • Time Factors
  • Tumor Necrosis Factor-alpha (blood)

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