[The search for new antiparasitic agents. 9. The anthelmintic activity of halogen-containing sulfonamidobenzamides].

Abstract

The results of preclinical trials of 28 new compounds of haloid-containing sulfamidobenzamides with low toxicity are presented. The trials on a hymenolepiasis model showed that effectiveness of N-(2,5-dichlorophenyl)-2/(3-nitro-4-chlorophenyl) sulfonylamino/-5-bromobenzamide was similar to that of the well-known drug niclosamide. In the trials on an opisthorchiasis model, 2 compounds were shown to be highly effective, and on a trichocephaliasis model 5 compounds showed a high activity.

• Authors: F S Mikhaĭlitsyn, M N Lebedeva, D G Baiandina, N P Kozyreva, N D Lychko, L A Bolotina, S K Drusviatskaia, A S Naĭdenova
• Journal: Meditsinskaia parazitologiia i parazitarnye bolezni (Med Parazitol (Mosk)) 1991 Nov-Dec Issue 6 Pg. 52-3 ISSN: 0025-8326 [Print] Russia (Federation)
• Vernacular Title: Izyskanie novykh protivoparazitarnykh sredstv. 9. Protivogel'mintnaia aktivnost' galoidsoderzhashchikh sul'fonamidobenzamidov.
• PMID: 1818252 (Publication Type: Comparative Study, English Abstract, Journal Article)

Chemical References

• Anthelmintics
• Benzamides
• Halogens
• Sulfonamides

Topics

• Animals
• Anthelmintics (therapeutic use)
• Benzamides (therapeutic use)
• Drug Evaluation, Preclinical
• Halogens (therapeutic use)
• Helminthiasis (drug therapy)
• Structure-Activity Relationship
• Sulfonamides (therapeutic use)