Cytologic malignancy versus benignancy: how useful are the "newer" markers in body fluid cytology?
Abstract | CONTEXT: Differentiating reactive effusion, malignant mesothelioma, and metastatic adenocarcinoma in body cavity fluids can be challenging. Interpreting immunohistochemical markers in cell block preparations can be difficult because of nonspecific staining, focal staining, or poor staining quality. We selected a panel of conventional and newer markers to assess their utility in evaluating effusions. OBJECTIVE: To evaluate the efficacy of 5 immunohistochemical markers in the differential diagnosis of reactive mesothelial proliferation, malignant mesothelioma, and metastatic adenocarcinoma in body cavity fluids. DESIGN: RESULTS: CONCLUSIONS: MOC-31 and D2-40 were very sensitive and specific markers of epithelial and mesothelial cells, respectively. Compared with calretinin, D2-40 was a more sensitive marker of mesothelial cells. WT1 proved to be nonspecific. XIAP was not a sensitive marker for malignancy and had a limited value in cytology. We recommend using a panel to include MOC-31 and D2-40 to improve diagnostic accuracy in body cavity effusions.
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Authors | Virganeyce Lyons-Boudreaux, Dina R Mody, Jim Zhai, Donna Coffey |
Journal | Archives of pathology & laboratory medicine
(Arch Pathol Lab Med)
Vol. 132
Issue 1
Pg. 23-8
(Jan 2008)
ISSN: 1543-2165 [Electronic] United States |
PMID | 18181669
(Publication Type: Evaluation Study, Journal Article)
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Chemical References |
- Antibodies, Monoclonal
- Antibodies, Monoclonal, Murine-Derived
- Biomarkers, Tumor
- CALB2 protein, human
- Calbindin 2
- S100 Calcium Binding Protein G
- WT1 Proteins
- X-Linked Inhibitor of Apoptosis Protein
- XIAP protein, human
- monoclonal antibody D2-40
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Topics |
- Adenocarcinoma
(chemistry, diagnosis, secondary)
- Antibodies, Monoclonal
(analysis)
- Antibodies, Monoclonal, Murine-Derived
- Biomarkers, Tumor
(analysis)
- Body Fluids
(chemistry, cytology)
- Calbindin 2
- Cell Proliferation
- Diagnosis, Differential
- Epithelium
(chemistry, pathology)
- Humans
- Hyperplasia
(diagnosis)
- Mesothelioma
(chemistry, diagnosis, secondary)
- Pleural Effusion, Malignant
(chemistry, cytology, diagnosis)
- S100 Calcium Binding Protein G
(analysis)
- WT1 Proteins
(analysis)
- X-Linked Inhibitor of Apoptosis Protein
(analysis)
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