[Biochemical and histological changes after acute oral poisoning with the acetanilide herbicide acetochlor].

Abstract

Changes in the liver of male rats were studied on the 1, 3, 5, 7, 10 and 14 days after a single oral application of 1/5 DL 50 of the chloracetanilic herbicide Acetochlor (DL50 = 1063 mg/kg-1). Two main periods in the action of acetochlor can be identified: between 1-2 days when the influence of the compound itself is predominant and between 5-7 days, when the toxic action of the slowly eliminated metabolites is most pronounced. These two periods provoke a biphasic activation/inhibition response of the liver. Remarkable is the compensatory effect of the cytochrome P-450 system responsible for the metabolism of acetochlor. The phase-specific changes were are followed by pathomorphological observations of liver tissue as well as by the time-course of the biochemical parameters studied in different liver fractions.

• Authors: G Antov, C Zaikov, A Bouzidi, S Mitova, A Michaelova, J Halkova, N Choumkov
• Journal: Journal de toxicologie clinique et experimentale (J Toxicol Clin Exp) Vol. 11 Issue 6 Pg. 349-56 (Oct 1991) ISSN: 0753-2830 [Print] France
• Vernacular Title: Modifications biochimiques et histologiques de l'intoxication orale aiguë par l'herbicide acétanilidique "acétochlore".
• PMID: 1818121 (Publication Type: English Abstract, Journal Article)

Chemical References

• Herbicides
• Toluidines
• acetochlor

Topics

• Administration, Oral
• Animals
• Herbicides (administration & dosage, poisoning)
• Liver (drug effects, pathology)
• Male
• Poisoning (pathology)
• Rats
• Rats, Inbred Strains
• Toluidines (administration & dosage, poisoning)