Abstract | CONTEXT: Although an association between mood disorders and substance use disorders has been well established, there is a lack of long-term prospective data on the order of onset and subtypes of mood disorders associated with specific substances and their progression. OBJECTIVE: DESIGN: Six waves of direct diagnostic interviews were administered to a sample of young adults during a 20-year period. Mood disorders and syndromes assessed at each interview were used to predict the cumulative incidences of substance use disorders at subsequent interview waves. PARTICIPANTS: We followed up 591 individuals (292 men and 299 women) who were selected at study enrollment from a representative sample of young adults in Zurich, Switzerland. MAIN OUTCOME MEASURES: Structured Diagnostic Interview for Psychopathologic and Somatic Syndromes, a semistructured clinical interview that collected data on the spectrum of expression of mood disorders and substance use and disorders for DSM-III-R and DSM-IV criteria. RESULTS: CONCLUSIONS: In comparison with major depression, bipolar II disorder was associated with the development of alcohol and benzodiazepine use and disorders. There was less specificity of manic symptoms that tended to predict all levels of the substances investigated herein. The different patterns of association between mood disorders and substance use trajectories have important implications for prevention and provide lacking information about underlying mechanisms.
|
Authors | Kathleen R Merikangas, Richard Herrell, Joel Swendsen, Wulf Rössler, Vladeta Ajdacic-Gross, Jules Angst |
Journal | Archives of general psychiatry
(Arch Gen Psychiatry)
Vol. 65
Issue 1
Pg. 47-52
(Jan 2008)
ISSN: 1538-3636 [Electronic] United States |
PMID | 18180428
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
|
Topics |
- Adult
- Bipolar Disorder
(epidemiology)
- Cohort Studies
- Comorbidity
- Female
- Humans
- Male
- Mood Disorders
(epidemiology)
- Risk
- Substance-Related Disorders
(epidemiology)
- Switzerland
(epidemiology)
|