Abstract | OBJECTIVE: Methicillin-resistant Staphylococcus aureus graft infection is one of the most serious complications of vascular surgery. Vancomycin is a potent antibiotic against methicillin-resistant S. aureus; however, systemic administration of vancomycin is not very effective against methicillin-resistant S. aureus graft infection. Therefore, we investigated whether a local sustained release of vancomycin prevents methicillin-resistant S. aureus graft infection. METHODS: RESULTS: The methicillin-resistant S. aureus counts in the grafts of the vancomycin-PLCA group were significantly lower than those of the other groups. Blood cultures of the vancomycin-PLCA group were all negative, whereas those of the other groups were all positive for infection. The survival rate in the vancomycin-PLCA group at 28 days was considerably higher than that in the control group (83.3% vs 16.7%). CONCLUSIONS: A local sustained-release sheet containing vancomycin reduced methicillin-resistant S. aureus counts in the infected vascular grafts, prevented sepsis, and drastically improved survival rates. This can be used as a highly effective and less-invasive adjunctive treatment method for preventing prosthetic methicillin-resistant S. aureus graft infection.
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Authors | Hisashi Sakaguchi, Akira Marui, Keiichi Hirose, Takamasa Nomura, Yoshio Arai, Shyamal Chandra Bir, Yuhong Huang, Jiro Esaki, Yasuhiko Tabata, Tadashi Ikeda, Masashi Komeda |
Journal | The Journal of thoracic and cardiovascular surgery
(J Thorac Cardiovasc Surg)
Vol. 135
Issue 1
Pg. 25-31
(Jan 2008)
ISSN: 1097-685X [Electronic] United States |
PMID | 18179914
(Publication Type: Journal Article)
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Chemical References |
- Anti-Bacterial Agents
- Caproates
- Delayed-Action Preparations
- Lactones
- Polyesters
- poly(lactide)
- caprolactone
- Vancomycin
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Topics |
- Absorbable Implants
- Administration, Topical
- Animals
- Anti-Bacterial Agents
(administration & dosage)
- Caproates
- Delayed-Action Preparations
- Disease Models, Animal
- Drug Delivery Systems
- Lactones
- Male
- Methicillin Resistance
- Polyesters
- Prosthesis-Related Infections
(microbiology, prevention & control)
- Rats
- Rats, Wistar
- Staphylococcal Infections
(complications, microbiology, prevention & control)
- Staphylococcus aureus
- Vancomycin
(administration & dosage)
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