Abstract |
The objective was to test the hypothesis that phenylbutazone (PBZ) alleviates lameness in an adjustable heart bar shoe model of equine foot pain. Eight Quarter Horse mares underwent 4-weekly treatments randomly: 0.9% saline placebo (SAL: 1 mL/45 kg body weight i.v.) with no lameness; SAL with lameness; PBZ (4.4 mg/kg body weight i.v.) with no lameness; and PBZ with lameness. Blinded heart rate (HR) and lameness score (LS) were assessed every 20 min for 2 h and then hourly through 9 h. At 1 h SAL or PBZ was administered. Jugular venous samples were obtained at hours 0, 1, 2, 4, 6, and 8 and were evaluated for packed cell volume (PCV), cortisol, and drug concentrations. Repeated measures anova and t-tests were used to identify PBZ effects at a significance level of P<0.05. PBZ-treated LS was lower 2-8 h post-treatment, and HR was lower from 2 through 6 h post-treatment (P<0.05). Phenylbutazone did not change PCV and had minimal effect on cortisol. Mean plasma PBZ and oxyphenbutazone concentrations 7 h after treatment were 7.2-7.5 and 1.6-1.9 microg/mL, respectively. It was concluded that PBZ was efficacious in alleviating lameness in this model. Cortisol and PCV were not discriminating enough to distinguish between PBZ-treated and SAL-treated trials.
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Authors | J H Foreman, A Barange, L M Lawrence, L L Hungerford |
Journal | Journal of veterinary pharmacology and therapeutics
(J Vet Pharmacol Ther)
Vol. 31
Issue 1
Pg. 39-44
(Feb 2008)
ISSN: 0140-7783 [Print] England |
PMID | 18177317
(Publication Type: Journal Article, Randomized Controlled Trial)
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Chemical References |
- Anti-Inflammatory Agents, Non-Steroidal
- Phenylbutazone
- Hydrocortisone
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Topics |
- Animals
- Anti-Inflammatory Agents, Non-Steroidal
(administration & dosage, therapeutic use)
- Female
- Forelimb
(injuries)
- Heart Rate
- Horses
(injuries)
- Hydrocortisone
(blood)
- Injections, Intravenous
(veterinary)
- Injury Severity Score
- Lameness, Animal
- Pain
(prevention & control, veterinary)
- Pain Measurement
(veterinary)
- Phenylbutazone
(administration & dosage, therapeutic use)
- Treatment Outcome
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