Abstract |
The effects of small-molecule p38 inhibitors in numerous models of different disease states have been published, including those of SD-282, an indole-5-carboxamide inhibitor. The aim of the present study was to evaluate the pharmacological activity of SD-282 on cytokine production in vitro as well as in 2 in vivo models of inflammation in order to illuminate the role of this particular inhibitor in diverse disease states. The results presented here provide further characterization of SD-282 and provide a context in which to interpret the activity of this p38 inhibitor in models of arthritis, pain, myocardial injury, sepsis and asthma; all of which have an inflammatory component. SD-282 represents a valuable tool to elucidate the role of p38 MAP kinase in multiple models of inflammation.
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Authors | Bruce Koppelman, Heather K Webb, Satyanarayana Medicherla, Ramona Almirez, Ying Feng, Jose Carlos Chavez, Cheng Ping Mao, Aaron Nguyen, Yu-Wang Liu, Ann M Kapoun, Gladys Muiru, Yuanying Anne Huang, Sundeep Dugar, Babu J Mavunkel, Don W Lim, Sarvajit Chakravarty, Gregory Luedtke, Andrew A Protter, Linda S Higgins |
Journal | Pharmacology
(Pharmacology)
Vol. 81
Issue 3
Pg. 204-20
( 2008)
ISSN: 1423-0313 [Electronic] Switzerland |
PMID | 18176091
(Publication Type: Journal Article)
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Copyright | Copyright 2008 S. Karger AG, Basel. |
Chemical References |
- Anti-Inflammatory Agents
- Enzyme Inhibitors
- Indoles
- Tumor Necrosis Factor-alpha
- indole-5-carboxamide
- Ovalbumin
- p38 Mitogen-Activated Protein Kinases
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Topics |
- Animals
- Anti-Inflammatory Agents
(pharmacology)
- Disease Models, Animal
- Enzyme Inhibitors
(pharmacokinetics, pharmacology)
- Female
- Granulocytes
(drug effects, metabolism)
- Guinea Pigs
- Humans
- In Vitro Techniques
- Indoles
(pharmacokinetics, pharmacology)
- Inflammation
(drug therapy)
- Lung
(drug effects, pathology)
- Male
- Mice
- Mice, Inbred BALB C
- Ovalbumin
- Sepsis
(drug therapy, physiopathology)
- Tumor Necrosis Factor-alpha
(blood, drug effects)
- p38 Mitogen-Activated Protein Kinases
(antagonists & inhibitors)
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