Changes in CCR2 chemokine receptor expression and plasma MCP-1 concentration after the implantation of bare metal stents versus sirolimus-eluting stents in patients with stable angina.

Abstract

BACKGROUND:

Although restenosis after successful coronary stenting is associated with changes in adhesion molecules and chemokines, it is unclear whether the differential effects of these molecules between a bare metal stent (BMS) and sirolimus-eluting stent (SES) may help to prevent coronary restenosis. The aim of this clinical study was to compare the expression levels of those molecules after elective placement of either a BMS or SES.

METHODS AND RESULTS:

The subjects included 32 consecutive patients with stable angina who had undergone successful coronary stenting and who randomly received either a BMS (n=16) or SES (n=16). Quantitative angiographic analysis 6 months after stenting showed that the minimal lumen diameter was significantly greater in the SES as compared to the BMS group, while the percent diameter stenosis and in-stent lumen loss were significantly lower. Plasma monocyte chemotactic protein-1 (MCP-1) increased significantly after 14 days and 6 months and monocyte CCR2 expression increased 24 hr and 48 hr after stenting in the BMS but not the SES group. Changes in plasma MCP-1 (DeltaMCP-1) within 6 months after stenting correlated significantly with in-stent lumen loss. The DeltaMCP-1 (between 6 months and baseline) was significantly related only to the lumen loss (r=0.443, p=0.023), which suggests that the reduction of MCP-1 is the best contributor to decreased lumen loss.

CONCLUSIONS:

These data suggest that reduction in MCP-1 production by SES may be one mechanism to prevent restenosis after coronary stenting.

• Authors: Hideto Sako, Shin-ichiro Miura, Atsushi Iwata, Hiroaki Nishikawa, Akira Kawamura, Kunihiro Matsuo, Kazuyuki Shirai, Keijiro Saku
• Journal: Internal medicine (Tokyo, Japan) (Intern Med) Vol. 47 Issue 1 Pg. 7-13 ( 2008) ISSN: 1349-7235 [Electronic] Japan
• PMID: 18175998 (Publication Type: Comparative Study, Journal Article, Randomized Controlled Trial)

Chemical References

• Autoantigens
• CCR2 protein, human
• Immunosuppressive Agents
• Receptors, CCR2
• metaphase chromosome protein 1, human
• Sirolimus

Topics

• Aged
• Angina Pectoris (blood, diagnostic imaging, therapy)
• Autoantigens (biosynthesis, blood)
• Coronary Angiography
• Coronary Restenosis (blood, diagnostic imaging, prevention & control)
• Drug-Eluting Stents
• Female
• Gene Expression
• Humans
• Immunosuppressive Agents (pharmacology)
• Male
• Middle Aged
• Receptors, CCR2 (biosynthesis)
• Sirolimus (pharmacology)
• Stents