Abstract |
Two new lignans, 4-methoxymagnaldehyde B (1) and coumanolignan (2), were isolated from the stem bark of Magnolia obovata, together with 11 known compounds (3-13). The structures of compounds 1 and 2 were determined to be 5'-allyl-2'-hydroxyphenyl-4-methoxy-3-cinnamic aldehyde (1) and 6-allyl-8-(5'-allyl-2'-hydroxyphenyl)coumarin (2) on the basis of spectroscopic and physicochemical analyses including 2D NMR and high-resolution EI-MS. Compounds 1-8, 11, 12, and 13 were tested in vitro for their cytotoxic activities against the HeLa, A549, and HCT116 cancer cell lines. Among the compounds tested, compound 1 showed the strongest cytotoxic activity against the HCT116 cancer cell line, with an IC(50) value of 1.3 microg/ml.
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Authors | UiJoung Youn, Quan Cheng Chen, Ik Soo Lee, HongJin Kim, Jae-Kuk Yoo, JongPill Lee, Minkyun Na, Byung-Sun Min, KiHwan Bae |
Journal | Chemical & pharmaceutical bulletin
(Chem Pharm Bull (Tokyo))
Vol. 56
Issue 1
Pg. 115-7
(Jan 2008)
ISSN: 0009-2363 [Print] Japan |
PMID | 18175990
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- 4-methoxymagnaldehyde B
- Antineoplastic Agents, Phytogenic
- Cinnamates
- Coumarins
- Lignans
- coumanolignan
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Topics |
- Antineoplastic Agents, Phytogenic
(chemistry, isolation & purification, pharmacology)
- Cinnamates
- Coumarins
- Drug Screening Assays, Antitumor
- HeLa Cells
- Humans
- Japan
- Lignans
(chemistry, isolation & purification, pharmacology)
- Magnolia
(chemistry)
- Molecular Structure
- Plant Bark
(chemistry)
- Plants, Medicinal
(chemistry)
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