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Two new lignans from the stem bark of Magnolia obovata and their cytotoxic activity.

Abstract
Two new lignans, 4-methoxymagnaldehyde B (1) and coumanolignan (2), were isolated from the stem bark of Magnolia obovata, together with 11 known compounds (3-13). The structures of compounds 1 and 2 were determined to be 5'-allyl-2'-hydroxyphenyl-4-methoxy-3-cinnamic aldehyde (1) and 6-allyl-8-(5'-allyl-2'-hydroxyphenyl)coumarin (2) on the basis of spectroscopic and physicochemical analyses including 2D NMR and high-resolution EI-MS. Compounds 1-8, 11, 12, and 13 were tested in vitro for their cytotoxic activities against the HeLa, A549, and HCT116 cancer cell lines. Among the compounds tested, compound 1 showed the strongest cytotoxic activity against the HCT116 cancer cell line, with an IC(50) value of 1.3 microg/ml.
AuthorsUiJoung Youn, Quan Cheng Chen, Ik Soo Lee, HongJin Kim, Jae-Kuk Yoo, JongPill Lee, Minkyun Na, Byung-Sun Min, KiHwan Bae
JournalChemical & pharmaceutical bulletin (Chem Pharm Bull (Tokyo)) Vol. 56 Issue 1 Pg. 115-7 (Jan 2008) ISSN: 0009-2363 [Print] Japan
PMID18175990 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • 4-methoxymagnaldehyde B
  • Antineoplastic Agents, Phytogenic
  • Cinnamates
  • Coumarins
  • Lignans
  • coumanolignan
Topics
  • Antineoplastic Agents, Phytogenic (chemistry, isolation & purification, pharmacology)
  • Cinnamates
  • Coumarins
  • Drug Screening Assays, Antitumor
  • HeLa Cells
  • Humans
  • Japan
  • Lignans (chemistry, isolation & purification, pharmacology)
  • Magnolia (chemistry)
  • Molecular Structure
  • Plant Bark (chemistry)
  • Plants, Medicinal (chemistry)

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