Modulation of apoptosis to reverse chemoresistance.

Abstract

Interference with the innate apoptotic activity is a hallmark of neoplastic transformation and tumor formation. Modulation of the apoptotic cascade has been proposed as a new approach for the treatment of cancer. In this chapter, we discuss the role of apoptosis in ovarian cancer and the use of phenoxodiol as a model for the regulation of apoptosis and potential use as chemosensitizer for chemoresistant ovarian cancer cells.

• Authors: Gil Mor, Michele K Montagna, Ayesha B Alvero
• Journal: Methods in molecular biology (Clifton, N.J.) (Methods Mol Biol) Vol. 414 Pg. 1-12 ( 2008) ISSN: 1064-3745 [Print] United States
• PMID: 18175807 (Publication Type: Evaluation Study, Journal Article, Review)

Chemical References

• Antineoplastic Agents
• Inhibitor of Apoptosis Proteins
• Isoflavones
• X-Linked Inhibitor of Apoptosis Protein
• phenoxodiol

Topics

• Animals
• Antineoplastic Agents (pharmacology, therapeutic use)
• Apoptosis (drug effects, genetics, physiology)
• Chemotherapy, Adjuvant
• Drug Resistance, Neoplasm (drug effects, genetics)
• Gene Expression Regulation, Neoplastic
• Humans
• Inhibitor of Apoptosis Proteins (physiology)
• Isoflavones (pharmacology, therapeutic use)
• Models, Biological
• Neoplasms (drug therapy)
• X-Linked Inhibitor of Apoptosis Protein (genetics)