[Clinical observation on treatment of male infertility with positive antisperm antibody by self-formulated Xiaokang Zhongzi Recipe].

Abstract

OBJECTIVE:

To observe the therapeutic effect of self-formulated Xiaokang Zhongzi Recipe (XZR) in treating male infertility with positive antisperm antibody (AsAb).

METHODS:

One hundred and ten male infertility patients with positive AsAb were randomly assigned, according to randomized digital table, to the trial group treated with XZR, and the control group, treated with prednisone, 55 in each group. Clinical therapeutic effect and adverse reactions of the drugs were observed after 3 months of treatment.

RESULTS:

In the trial group after treatment, 38 patients (69.1%) were cured, 14 (25.4%) improved and 3 treated in vain (5.5%, including 2 dropped out). While in the control group, the corresponding numbers were 12 (21.8%), 11 (20.0%) and 32 (58.2%, including 4 dropped out, 20 remained AsAb positive and 8 with AsAb reverted to positive after negative conversion). The negative conversion rate and average negative conversion time in the trial group and the control group were respectively 94.5%, (45 +/- 14) days and 41.8%, (62 +/- 21) days. Significant difference between the two groups was shown in therapeutic effectiveness and average negative conversion time (P < 0.01). Adverse reactions occurred in 3 cases (5.5%) in the trial group and 8 (14.5%) in the control group.

CONCLUSION:

XZR is better than prednisone in treating male infertility with positive AsAb, and with fewer and milder adverse reactions.

• Authors: Tian-shou Qi, Guo-qing Li, Gui-jiang Xu
• Journal: Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine (Zhongguo Zhong Xi Yi Jie He Za Zhi) Vol. 27 Issue 11 Pg. 983-5 (Nov 2007) ISSN: 1003-5370 [Print] China
• PMID: 18173141 (Publication Type: English Abstract, Journal Article, Randomized Controlled Trial)

Chemical References

• Autoantibodies
• Drugs, Chinese Herbal
• xiaokang zhongzi

Topics

• Adult
• Autoantibodies (blood)
• Drugs, Chinese Herbal (therapeutic use)
• Humans
• Infertility, Male (drug therapy, etiology, immunology)
• Male
• Phytotherapy
• Spermatozoa (drug effects, immunology)
• Treatment Outcome
• Young Adult