Abstract | BACKGROUND: METHODS: Between 1988 and 2004, 24 patients with cIS stage NSGCT were evaluated and treated at Memorial Sloan-Kettering Cancer Center. Clinical and pathologic data were obtained from the institutional prospective database. Seven patients underwent primary RPLND, and 17 patients received induction chemotherapy as initial management. Clinical outcomes, patterns of relapse, and pathologic findings were reported. RESULTS: Six of the 7 patients who underwent primary RPLND had viable germ cell tumor (GCT) present. Four of those patients did not receive adjuvant chemotherapy, and all experienced systemic relapse. Of the 17 patients who received induction chemotherapy, 3 patients underwent elective postchemotherapy RPLND (PC-RPLND), and 14 patients were followed expectantly. Four patients who were followed expectantly relapsed in the retroperitoneum and underwent PC-RPLND. Of the 7 patients who underwent PC-RPLND, 1 patient had fibrosis (14%), but 6 patients (86%) had teratoma, including 1 patient who also had a viable GCT in the retroperitoneum. Overall, the incidence of teratoma or viable GCT in the retroperitoneum after chemotherapy was 43% (6 of 14 patients). At a median follow-up of 35 months, 23 men remained alive, and 1 man had died of disease. CONCLUSIONS: The current data suggest that patients with cIS stage NSGCT will benefit from adjuvant PC-RPLND.
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Authors | Atreya Dash, Brett S Carver, Jason Stasi, Dean F Bajorin, Robert J Motzer, George J Bosl, Joel Sheinfeld |
Journal | Cancer
(Cancer)
Vol. 112
Issue 4
Pg. 800-5
(Feb 15 2008)
ISSN: 0008-543X [Print] United States |
PMID | 18172902
(Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)
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Copyright | Cancer 2008. (c) 2008 American Cancer Society. |
Topics |
- Chemotherapy, Adjuvant
- Combined Modality Therapy
- Humans
- Lymph Node Excision
- Male
- Neoplasm Recurrence, Local
- Neoplasm Staging
- Neoplasms, Germ Cell and Embryonal
(mortality, pathology, therapy)
- Survival Rate
- Teratoma
(drug therapy, pathology, surgery)
- Testicular Neoplasms
(mortality, pathology, therapy)
- Treatment Outcome
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