Abstract | PURPOSE: METHODS AND MATERIALS: Six patients with cervical cancer underwent conventional HDR (C-HDR) treatment. Computed tomography (CT) and magnetic resonance imaging (MRI) scans were acquired with a CT/MRI-compatible applicator in place. The clinical target volumes (CTVs), defined as the gross target volume with a 3-mm margin and the uterus, were delineated on the CT scans, along with the organs at risk (OARs). The IMRT plans were optimized to generate dose distributions complementing those of C-HDR to cover the CTV while maintaining low doses to the OARs (IMRT-HDR). For comparison, dwell-weight optimized HDR (O-HDR) plans were also generated to cover the CTV and spare the OARs. The three treatment techniques (C-HDR, O-HDR, and IMRT-HDR) were compared. The percentage of volume receiving 95% of the prescription dose (V(95)) was used to evaluate dose coverage to the CTV, and the minimal doses in the 2.0-cm(3) volume receiving the greatest dose were calculated to compare the doses to the OARs. RESULTS: The C-HDR technique provided very poor CTV coverage in 5 cases (V(95) <62%). Although O-HDR provided excellent gross tumor volume coverage (V(95) > or =96.9%), it resulted in unacceptably high doses to the OARs in all 6 cases and unsatisfactory coverage to the whole CTV in 3 cases. IMRT-HDR not only yielded substantially improved CTV coverage (average V(95) = 95.3%), but also kept the doses to the bladder and rectum reasonably low. CONCLUSION: Compared with C-HDR and O-HDR, concomitant IMRT boost complementary to C-HDR not only provided excellent CTV coverage, but also maintained reasonably low doses to the OARs.
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Authors | Jun Duan, Robert Y Kim, Shaaban Elassal, Hui-Yi Lin, Sui Shen |
Journal | International journal of radiation oncology, biology, physics
(Int J Radiat Oncol Biol Phys)
Vol. 71
Issue 3
Pg. 765-71
(Jul 01 2008)
ISSN: 0360-3016 [Print] United States |
PMID | 18164832
(Publication Type: Clinical Trial, Journal Article)
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Topics |
- Brachytherapy
(methods)
- Combined Modality Therapy
- Dose Fractionation, Radiation
- Female
- Humans
- Radiotherapy, Conformal
(methods)
- Treatment Outcome
- Uterine Cervical Neoplasms
(radiotherapy)
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