Characterization and antitumor activity of triethylene tetramine, a novel telomerase inhibitor.

Abstract	Triethylene tetramine (TETA) is a novel ligand for G-quadruplex and has been reported to have many kinds of biological activities, including telomerase inhibition, inducing the senescence of tumor cells, etc. In this study, tumor inhibiting activity of TETA and its mechanism were investigated in HeLa cells, MCF-7 cells and mice transplanted with S180 tumor. Results indicated that TETA inhibited telomerase activity involved in decreasing the expression of human telomerase reverse transcriptase (hTERT). We also observed that a low concentration of TETA had limited ability to inhibit the growth of tumor cells in short-term culture, but it could significantly enhance antitumor activity of traditional antitumor drugs in vitro and in vivo.
Authors	Jianhui Liu, Lixia Guo, Fei Yin, Xuxu Zheng, Gang Chen, Yun Wang
Journal	Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie (Biomed Pharmacother) Vol. 62 Issue 7 Pg. 480-5 (Sep 2008) ISSN: 0753-3322 [Print] France
PMID	18164582 (Publication Type: Letter, Research Support, Non-U.S. Gov't)
Chemical References	Antibiotics, Antineoplastic Antineoplastic Agents Antineoplastic Agents, Alkylating Antineoplastic Agents, Phytogenic Indicators and Reagents Tetrazolium Salts Thiazoles Doxorubicin Cyclophosphamide Carboplatin Telomerase thiazolyl blue Paclitaxel Trientine
Topics	Animals Antibiotics, Antineoplastic (pharmacology) Antineoplastic Agents (pharmacology) Antineoplastic Agents, Alkylating (therapeutic use) Antineoplastic Agents, Phytogenic (pharmacology) Blotting, Western Carboplatin (pharmacology) Cell Line, Tumor Cell Proliferation (drug effects) Cyclophosphamide (therapeutic use) Doxorubicin (pharmacology) Female HeLa Cells Humans Indicators and Reagents Mice Paclitaxel (pharmacology) Reverse Transcriptase Polymerase Chain Reaction Sarcoma 180 (drug therapy) Telomerase (antagonists & inhibitors) Tetrazolium Salts Thiazoles Trientine (pharmacology)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.

Realize the full power of the drug-disease research graph!