[Hemodynamic response of patients with arterial hypertension to graded pedal isometric exercise after administration of vasodilators of different classes].

Abstract

Graded isometric exercise (IE) testing was performed to study the effects of vasodilators from various classes on the hemodynamic response in 60 patients with mild and moderate essential hypertension (EH). Hemodynamic parameters were determined by rheography. Group I patients took captopril, 50 mg, Group II prazosin, 2 mg, and Group III nifedipine, 20 mg. Hemodynamic changes tended to deteriorate in patients with the EH syndrome during IET. Application of the vasodilators led to the alleviation of the changes both at rest and during IET, as manifested by lower absolute values of the parameters and their relative increase. The beneficial influences of drugs from various classes on some hemodynamic parameters were different.

• Authors: Iu N Ziiaev, N P Nikitin, G Sh Shakha
• Journal: Kardiologiia (Kardiologiia) Vol. 31 Issue 12 Pg. 38-42 (Dec 1991) ISSN: 0022-9040 [Print] Russia (Federation)
• Vernacular Title: Gemodinamicheskiĭ otvet bol'nykh s arterial'noĭ gipertenzieĭ na dozirovannuiu nozhnuiu izometricheskuiu nagruzku pod vliianiem vazodilatatorov razlichnykh klassov.
• PMID: 1816439 (Publication Type: Clinical Trial, Comparative Study, Controlled Clinical Trial, English Abstract, Journal Article)

Chemical References

• Antihypertensive Agents
• Vasodilator Agents
• Captopril
• Nifedipine
• Prazosin

Topics

• Adult
• Aged
• Antihypertensive Agents (classification, therapeutic use)
• Captopril (therapeutic use)
• Drug Evaluation
• Exercise Test
• Female
• Hemodynamics (drug effects, physiology)
• Humans
• Hypertension (drug therapy, physiopathology)
• Male
• Middle Aged
• Nifedipine (therapeutic use)
• Prazosin (therapeutic use)
• Vasodilator Agents (classification, therapeutic use)