BRCA1--sowing the seeds crooked in the furrow.

Abstract

Breast tumors with deficiency in DNA double-strand break repair might be expected to show aneuploidy. A new study shows that microdeletions in PTEN, resulting in complete loss of PTEN protein, are signature lesions in these cancers, particularly those arising in BRCA1-mutation carriers.

• Authors: William D Foulkes
• Journal: Nature genetics (Nat Genet) Vol. 40 Issue 1 Pg. 8-9 (Jan 2008) ISSN: 1546-1718 [Electronic] United States
• PMID: 18163127 (Publication Type: News)

Chemical References

• BRCA1 Protein
• PTEN Phosphohydrolase

Topics

• BRCA1 Protein (genetics)
• Breast Neoplasms (drug therapy, genetics)
• Humans
• Models, Biological
• PTEN Phosphohydrolase (genetics)