[Erythrocytic membrane status (as cell model) in cases of severe cranium-face trauma: possibilities for correction].

Abstract

Acute posttraumatic period of severe maxillofacial trauma in case of hyperbaric oxygenation therapy is followed by expressed activation of lipide-peroxide-oxidation (LPO) in erythrocytic membrane on the background of significant reduction of the substrate for fermentative antioxidation system (AOS). Imbalance in the system LPO:AOS is followed by expressed structural reorganization in erythrocytic membrane and build-up extraerythrocytic haemoglobin in plasma. Klonidine promotes LPO activity reduction and prevents depletion of AOS fermentative capacity in membrane that is followed by normalization of structural-functional interrelations in membrane and reduction of the level of extraerythrocytic haemoglobin in plasma.

• Authors: N B Karmen, N P Miliutina, A M Zakarov, E I Maevskĭ, V P Ippolitov
• Journal: Stomatologiia (Stomatologiia (Mosk)) Vol. 86 Issue 5 Pg. 15-9 ( 2007) ISSN: 0039-1735 [Print] Russia (Federation)
• PMID: 18163056 (Publication Type: Controlled Clinical Trial, English Abstract, Journal Article)

Chemical References

• Adrenergic alpha-Agonists
• Hemoglobins
• Malondialdehyde
• Catalase
• Superoxide Dismutase
• Clonidine

Topics

• Adrenergic alpha-Agonists (pharmacology, therapeutic use)
• Adult
• Catalase (analysis)
• Clonidine (therapeutic use)
• Craniocerebral Trauma (diagnosis, drug therapy)
• Erythrocyte Membrane (chemistry, drug effects)
• Female
• Hemoglobins (analysis)
• Humans
• Lipid Peroxidation (drug effects)
• Male
• Malondialdehyde (analysis)
• Superoxide Dismutase (analysis)
• Viscosity