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Activated protein C resistance and factor V Leiden in Mexico.

Abstract
A common cause of hereditary thrombophilia is activated protein C resistance (APCR), and most cases result from factor V Leiden mutation. An APCR phenotype without association with factor V Leiden has been described. This transversal, observational, nonrandomized study evaluated these 2 phenomena in healthy indigenous and mestizo Mexican subjects (n = 4345), including 600 Mexican natives. No indigenous subjects had APCR, but 82 mestizo subjects did. After retesting, 50 subjects had a negative test. The remaining 32 subjects had factor V Leiden, giving a 0.85% prevalence of factor V Leiden in the mestizo Mexican population. Only 31% of APCR carriers had factor V Leiden. These results show a very low prevalence of APCR and factor V Leiden in Mexico. Except for factor V Leiden, there are no other mutations in the factor V gene responsible for the APCR phenotype. Acquired APCR is nearly twice as prevalent as the inherited variant.
AuthorsAbraham Majluf-Cruz, Manuel Moreno-Hernández, Adriana Ruiz-de-Chávez-Ochoa, Rosario Monroy-García, Karim Majluf-Cruz, Rodolfo Guardado-Mendoza, Irma Molina-Avila, Irma Isordia-Salas, Norma Corona-de la Peña, Florencia Vargas-Vorackova, Jorge Vela-Ojeda, Jaime García-Chávez
JournalClinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis (Clin Appl Thromb Hemost) Vol. 14 Issue 4 Pg. 428-37 (Oct 2008) ISSN: 1076-0296 [Print] United States
PMID18160617 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • factor V Leiden
  • Factor V
Topics
  • Activated Protein C Resistance (epidemiology)
  • Adolescent
  • Adult
  • Aged
  • Cross-Sectional Studies
  • Factor V (analysis)
  • Female
  • Humans
  • Male
  • Mexico (epidemiology)
  • Middle Aged
  • Prevalence

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