Bobel-24 activity against Cryptosporidium parvum in cell culture and in a SCID mouse model.

Abstract	The anticryptosporidial activity of Bobel-24 (2,4,6-triiodophenol) was studied for the first time, resulting in a reduction of the in vitro growth of Cryptosporidium of up to 99.6%. In a SCID mouse model of chronic cryptosporidiosis, significant differences (P < 0.05) in oocyst shedding were observed in animals treated with 125 mg/kg/day. These results merit further investigation of Bobel-24 as a chemotherapeutic option for cryptosporidiosis.
Authors	Cristina Rueda, Soledad Fenoy, Fernando Simón, Carmen Del Aguila
Journal	Antimicrobial agents and chemotherapy (Antimicrob Agents Chemother) Vol. 52 Issue 3 Pg. 1150-2 (Mar 2008) ISSN: 0066-4804 [Print] United States
PMID	18160525 (Publication Type: Journal Article)
Chemical References	Antiprotozoal Agents Culture Media Phenols 2,4,6-triiodophenol
Topics	Animals Antiprotozoal Agents (chemistry, pharmacology, therapeutic use) Cryptosporidiosis (drug therapy, parasitology) Cryptosporidium parvum (drug effects, growth & development) Culture Media Disease Models, Animal Female Humans Mice Mice, SCID Phenols (chemistry, pharmacology, therapeutic use) Treatment Outcome

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