Antidiabetic properties of 2,5-dihydroxy-4,3'-di(beta-D-glucopyranosyloxy)-trans-stilbene from mulberry (Morus bombycis koidzumi) root in streptozotocin-induced diabetic rats.

We investigated the antidiabetic properties of 2,5-dihydroxy-4,3-di(beta-D-glucopyranosyloxy)-trans-stilbene (DGTS) isolated from Morus bombycis Koidzumi in streptozotocin (STZ)-induced diabetic rats. The DGTS prevented the increase in aspartate aminotransferase, alanine aminotransferase, and blood urea nitrogen levels in serum of diabetic rats. At doses of 200-800 mg/kg, DGTS improved hyperglycemia in the rats, and the hypoglycemic effect of DGTS was comparable to that of tolbutamide. The histological observations showed that DGTS prevented atrophy of pancreatic beta-cells and vascular degenerative changes in the islets. DGTS reversed STZ-induced diabetes and had antioxidant activity in assays of FeCl(2)/ascorbic acid-induced lipid peroxidation in the rats. Levels of cytochrome P450 2E1 mRNA, as measured by reverse transcription-polymerase chain reaction, were lower in the livers of the DGTS-treated rats than those of the control group. These results suggest that DGTS might be beneficial in the treatment of type 1 diabetes.
AuthorsSeong-Il Heo, Ying-Shan Jin, Mee Jung Jung, Myeong-Hyeon Wang
JournalJournal of medicinal food (J Med Food) Vol. 10 Issue 4 Pg. 602-7 (Dec 2007) ISSN: 1096-620X [Print] United States
PMID18158829 (Publication Type: Journal Article)
Chemical References
  • 2,5-dihydroxy-4,3'-di(beta-d-glucopyranosyloxy)-trans-stilbene
  • Blood Glucose
  • Hypoglycemic Agents
  • Insulin
  • Stilbenes
  • Cytochrome P-450 CYP2E1
  • Animals
  • Blood Glucose (analysis)
  • Cytochrome P-450 CYP2E1 (genetics)
  • Diabetes Mellitus, Experimental (drug therapy, metabolism, pathology)
  • Gene Expression (drug effects)
  • Hypoglycemic Agents (therapeutic use)
  • Insulin (blood)
  • Islets of Langerhans (pathology)
  • Lipid Peroxidation (drug effects)
  • Male
  • Morus (chemistry)
  • Plant Roots (chemistry)
  • Rats
  • Rats, Sprague-Dawley
  • Stilbenes (therapeutic use)

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