Profiling of radicular cyst and odontogenic keratocyst cytokine production suggests common growth mechanisms.

Abstract

The aim of this study was to compare the cytokine expression profiles of cyst fluids (CFs) and tissue culture supernatants (SUPs) from 7 radicular cysts (RCs) and 7 odontogenic keratocysts (OKCs) by using Human Cytokine Antibody Array to identify the specific cytokines involved in formation and expansion of RCs and OKCs, respectively. There were significant differences in relative expression levels of IL-1 beta, MCP1, MIP1 beta, FGF-9, GDNF, HGF, IGFBP-3, Ang, IP-10, MIF, OPG, and TGF-beta2 between RC-CF and OKC-CF (P < .05). On the other hand, the cytokine expression patterns of RC-SUP (HGF, IL-8, NAP-2, IL-6, TIMP-1 and 2, GRO, IP-10, and Ang) were similar to those of OKC-SUP. Only the relative expression level of GRO differed between RC-SUP and OKC-SUP (P < .05). The similarities of cytokine production by tissue cultures derived from RC and OKC indicate that the expansion mechanisms of RC and OKC might involve similar biologic mechanisms other than infection.

• Authors: Makoto Hayashi, Takafumi Ohshima, Mitsuhiro Ohshima, Yoko Yamaguchi, Hirofumi Miyata, Osamu Takeichi, Bunnai Ogiso, Koichi Ito, Arne Ostman, Kichibee Otsuka
• Journal: Journal of endodontics (J Endod) Vol. 34 Issue 1 Pg. 14-21 (Jan 2008) ISSN: 0099-2399 [Print] United States
• PMID: 18155485 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Cytokines
• RNA, Messenger

Topics

• Adult
• Cytokines (analysis, biosynthesis)
• Female
• Humans
• Male
• Mandibular Diseases (metabolism)
• Maxillary Diseases (metabolism)
• Middle Aged
• Odontogenic Cysts (metabolism)
• Protein Array Analysis (methods)
• RNA, Messenger (analysis)
• Radicular Cyst (metabolism)
• Statistics, Nonparametric