A study of the sensitization rate to cocamidopropyl betaine in patients patch tested in a university hospital of Beijing.

Abstract

BACKGROUND:

The prevalence of sensitization to cocamidopropyl betaine (CAPB) in China has not been reported.

OBJECTIVE:

This study is to evaluate the prevalence of CAPB sensitization in patients patch tested in Peking University Third Hospital, Beijing.

METHODS:

429 consecutive patients with suspected allergic contact dermatitis were patch tested with CAPB 1.0% aqueous, 3-dimethylaminopropylamine (DMAPA) 1.0% aqueous as well as a modified European standard series of allergens from June 2005 to August 2006.

RESULTS:

42 patients (9.8%) had a positive reaction to CAPB. 25 of them (59.5%) were considered relevant. Of those, 7 were head and/or neck dermatitis, 4 hand dermatitis, 1 cheilitis, and the other 13 patients were widespread dermatitis. 10 out of 429 (2.3%) patients reacted to DMAPA. Of those, 8 were relevant and 6 of them also reacted to CAPB.

CONCLUSION:

The rate of CAPB sensitization in our study is higher than previously reported elsewhere. CAPB is a common cosmetic allergen in Beijing. Both CAPB and DMAPA should be tested in patients with suspected cosmetic dermatitis.

• Authors: Lin-Feng Li
• Journal: Contact dermatitis (Contact Dermatitis) Vol. 58 Issue 1 Pg. 24-7 (Jan 2008) ISSN: 1600-0536 [Electronic] England
• PMID: 18154554 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Cosmetics
• Diamines
• Surface-Active Agents
• Betaine
• cocamidopropyl betaine
• 3-dimethylaminopropylamine

Topics

• Adolescent
• Adult
• Aged
• Aged, 80 and over
• Betaine (adverse effects, analogs & derivatives)
• Child
• China (epidemiology)
• Cosmetics (adverse effects)
• Dermatitis, Allergic Contact (diagnosis, epidemiology, etiology)
• Diamines (adverse effects)
• Female
• Hospitals, University
• Humans
• Male
• Middle Aged
• Patch Tests
• Prevalence
• Surface-Active Agents (adverse effects)