Great efforts have been made to develop non-occlusive or non-ever-lasting-occlusive
contraception devices in vas deferens during the recent decade at home and abroad. In our previous studies both in vivo and in vitro,
polymer HFMC was found to have a spermicidal effect. In this investigation in SD rats, the relationship between the concentration of
HFMC injected into the vas deferens and the resumption of fertility was studied by means of continual observations on the existence of sperms in vaginal smears from the caged female and on pup-birth delaying, so as to determine occlusion of the vas lumen and the effect of
HFMC on
contraception in male. The histopathological changes in the vas deferens and caudal epididymis of the
HFMC-injected male rats were also observed. The results indicated: (1)
HFMC in concentration over 7.5% could show temporary
contraception effect by its slow releasing of H+; (2)
HFMC could induce definite
contraception effect which lasted longer as the concentration of
HFMC given increased; (3)
HFMC had no effect on the descendents in number, mortality, sex ratio,
body weight and appearance; (4) the bilateral internal reproductive structures were identified normal after resumption of fertility, but 20%
HFMC induced vas deferens occlusion and
spermatoceles; (5) moderate concentration of
HFMC was considered favorable for reversible intra-vas deferens
contraception.