Improved posthypoxic recovery with a membrane-permeable calpain inhibitor.

Abstract	In vitro hippocampal slices from adult rats were subjected to transient hypoxia in the presence of a cell-penetrating, calpain inhibitor (Cbz-Val-Phe-H; MDL-28170). The posthypoxic recovery of synaptic potentials was greatly improved in protease inhibitor-treated slices relative to control slices. These findings support a role for calcium-activated proteolysis in the process of hypoxic pathophysiology.
Authors	L Arlinghaus, S Mehdi, K S Lee
Journal	European journal of pharmacology (Eur J Pharmacol) Vol. 209 Issue 1-2 Pg. 123-5 (Dec 10 1991) ISSN: 0014-2999 [Print] Netherlands
PMID	1814757 (Publication Type: Journal Article)
Chemical References	Dipeptides Calpain calpain inhibitor III
Topics	Animals Calpain (antagonists & inhibitors) Cell Death (drug effects) Cell Membrane Permeability (drug effects) Dipeptides (pharmacology) Hippocampus (anatomy & histology, drug effects, enzymology) Hypoxia (drug therapy, enzymology) Rats Rats, Inbred Strains

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