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A hemA mutation renders Salmonella typhimurium avirulent in mice, yet capable of eliciting protection against intravenous infection with S. typhimurium.

Abstract
The hemA mutation reduces the virulence of Salmonella typhimurium for mice by at least 10(7)-fold, as measured by change in LD50. The hemA mutation does not appear to affect killing of salmonella in mice. The salmonella with the hemA mutation persist in the spleen and liver for 2 to 3 weeks following intravenous injection. The most likely effect of the hemA mutation is to block, or retard, growth of S. typhimurium in an aerobic in vivo environment. Intravenous vaccination of susceptible ltys mice with hemA salmonella was able to elicit about 4 logs of protection against invasive infection with wild-type S. typhimurium 78 days after vaccination, at a time when the vaccine strain was no longer detectable in the spleen and liver.
AuthorsW H Benjamin Jr, P Hall, D E Briles
JournalMicrobial pathogenesis (Microb Pathog) Vol. 11 Issue 4 Pg. 289-95 (Oct 1991) ISSN: 0882-4010 [Print] England
PMID1813780 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, Non-P.H.S., Research Support, U.S. Gov't, P.H.S.)
Chemical References
  • Bacterial Proteins
  • Aldehyde Oxidoreductases
  • glutamyl tRNA reductase
Topics
  • Aldehyde Oxidoreductases (genetics)
  • Animals
  • Bacterial Proteins (genetics)
  • Female
  • Liver (microbiology)
  • Male
  • Mice
  • Mice, Inbred BALB C
  • Mutation
  • Salmonella Infections, Animal (microbiology, prevention & control)
  • Salmonella typhimurium (genetics, immunology, isolation & purification, pathogenicity)
  • Spleen (microbiology)
  • Vaccination
  • Virulence

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