Gastric antisecretory activity of 15(R)-15-methylprostaglandin E2, arbaprostil, in dogs.

Abstract

The gastric antisecretory activity of 15(R)-15-methylprostaglandin E2 (arbaprostil) was compared with that of natural prostaglandin (PG) E2 in Pavlov pouch dogs. Arbaprostil significantly inhibited pentagastrin- and food-stimulated gastric secretion when it was administered directly into the pouch at a dose of 10-30 micrograms/pouch and 30-300 micrograms/pouch, respectively. Natural PGE2, however, was inactive up to 1000 micrograms/pouch. The data indicate that arbaprostil is a potent, long-acting orally active antisecretory drug that may be useful for the treatment of peptic ulcer disease.

• Authors: H Takanashi, Z Itoh
• Journal: Japanese journal of pharmacology (Jpn J Pharmacol) Vol. 57 Issue 3 Pg. 447-51 (Nov 1991) ISSN: 0021-5198 [Print] Japan
• PMID: 1813671 (Publication Type: Comparative Study, Journal Article)

Chemical References

• Pentagastrin
• Dinoprostone
• Arbaprostil

Topics

• Animals
• Arbaprostil (adverse effects, pharmacology)
• Diarrhea (chemically induced)
• Dinoprostone (adverse effects, pharmacology)
• Dogs
• Eating (physiology)
• Female
• Gastric Acid (metabolism)
• Gastric Mucosa (drug effects, metabolism)
• Male
• Pentagastrin (pharmacology)
• Vagus Nerve (physiology)