HOMEPRODUCTSSERVICESCOMPANYCONTACTFAQResearchDictionaryPharmaMobileSign Up FREE or Login

[Malignant histiocytosis: a study on clinicopathological features and cell origin].

Abstract
Thirty-one autopsy cases previously diagnosed as malignant histiocytosis (MH) were studied by means of immunohistochemical staining. Antibodies detecting the formalin resistant epitopes on T-cells, B-cells and those of histiocyte/monocyte origin were used. It was shown that the malignant histiocytes reacted only to the cell markers derived from histiocyte/monocyte, and only a part of lymphocytes showed positive reaction to the T and B cell markers. It is suggested that the histiocyte/monocyte lineage is the possible origin of the malignant proliferating cells in MH. The clinicopathological features and the differentiation of MH from familial erythrophagocytic lymphohistiocytosis, virus-associated hemophagocytic syndrome and malignant lymphoma are described. The pathogenesis, the causes of death and the points for attention in the treatment of MH are also discussed.
AuthorsP J Li
JournalZhonghua bing li xue za zhi Chinese journal of pathology (Zhonghua Bing Li Xue Za Zhi) Vol. 20 Issue 4 Pg. 250-3 (Dec 1991) ISSN: 0529-5807 [Print] CHINA
PMID1813156 (Publication Type: English Abstract, Journal Article)
Topics
  • Child
  • Child, Preschool
  • Female
  • Histiocytes (pathology)
  • Histiocytic Sarcoma (pathology)
  • Humans
  • Immunohistochemistry
  • Infant
  • Male
  • Monocytes (pathology)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research network!


Choose Username:
Email:
Password:
Verify Password: