[Malignant histiocytosis: a study on clinicopathological features and cell origin].

Thirty-one autopsy cases previously diagnosed as malignant histiocytosis (MH) were studied by means of immunohistochemical staining. Antibodies detecting the formalin resistant epitopes on T-cells, B-cells and those of histiocyte/monocyte origin were used. It was shown that the malignant histiocytes reacted only to the cell markers derived from histiocyte/monocyte, and only a part of lymphocytes showed positive reaction to the T and B cell markers. It is suggested that the histiocyte/monocyte lineage is the possible origin of the malignant proliferating cells in MH. The clinicopathological features and the differentiation of MH from familial erythrophagocytic lymphohistiocytosis, virus-associated hemophagocytic syndrome and malignant lymphoma are described. The pathogenesis, the causes of death and the points for attention in the treatment of MH are also discussed.
AuthorsP J Li
JournalZhonghua bing li xue za zhi Chinese journal of pathology (Zhonghua Bing Li Xue Za Zhi) Vol. 20 Issue 4 Pg. 250-3 (Dec 1991) ISSN: 0529-5807 [Print] CHINA
PMID1813156 (Publication Type: English Abstract, Journal Article)
  • Child
  • Child, Preschool
  • Female
  • Histiocytes (pathology)
  • Histiocytic Sarcoma (pathology)
  • Humans
  • Immunohistochemistry
  • Infant
  • Male
  • Monocytes (pathology)

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