Meclofenamic acid has been successfully used in several obstetrical and gynecological disorders sustained by a
prostaglandin overproduction. A brief review of
meclofenamic acid use for primary
dysmenorrhea,
menorrhagia, and
episiotomy pain is followed by an original study of this compound in
postsurgical pain and stress. Thirty gynecological patients undergoing abdominal
hysterectomy and 10 pregnant women submitted to
cesarean section at term were considered. In gynecological patients,
meclofenamic acid suppositories (200 mg) or placebo were given every 12 h during the immediate postsurgical period; pregnant women were given the active
drug only. Subjective
pain was evaluated [through visual analogue scale (VAS)] in basal conditions (2 h from the end of surgery) and 2, 4, 6, 24, and 28 h from the first
drug dose. At the same time, blood was drawn for the evaluation of plasma cortical levels (through coated-tube radioimmunoassay). A significant
pain relief was obtained after only 4 h posttreatment both in gynecological patients and pregnant women.
Meclofenamic acid was superior to placebo from 6 h
after treatment and it almost suppressed subjective
pain at the end of the observation period (28th h).
Cortisol levels were already high at the basal evaluation and showed a further increase during the first postsurgery hours. Patients treated with
meclofenamic acid had
cortisol values lower than those who were treated with placebo. The former recovered normal levels after 24 h, whereas the latter already had increased values. These data demonstrate that
meclofenamic acid is a safe, powerful and specific
analgesic for the postsurgical period. The reduction of
pain stimulation is also accompanied by a reduced activation of the neuroendocrine axis with a prompt recovery from postsurgical stress.