Pharmacological and toxicological studies on new Rh(I) organometallic complexes.

Abstract

New rhodium(I) complexes, belonging to the general structure [Rh(CO)2 (L)], where dithiocarbamate and xanthate derivatives, were synthesized and assayed as cytostatic and antitumour agents in vitro against KB cells and in vivo against P388 leukaemia, Ehrlich ascites carcinoma, Sarcoma 180 ascites and ADJ/PC6A solid tumour. Assays against five trypanosoma strains were also performed. Among the new compounds the [Rh(CO)2 (DPA-dtc)] appeared to be active in all biological systems without showing evident nephrotoxicity.

• Authors: D G Craciunescu, V Scarcia, A Furlani, A Papaioannou, E Parrondo Iglesias, M P Alonso
• Journal: In vivo (Athens, Greece) (In Vivo) 1991 Jul-Aug Vol. 5 Issue 4 Pg. 329-32 ISSN: 0258-851X [Print] Greece
• PMID: 1810417 (Publication Type: Journal Article)

Chemical References

• Organometallic Compounds
• Thiocarbamates
• dicarbonyldiphenylaminedithiocarbamate rhodium(I)
• Rhodium

Topics

• Evaluation Studies as Topic
• Humans
• Kidney (drug effects)
• Neoplasms, Experimental (drug therapy)
• Organometallic Compounds (chemistry, pharmacology, toxicity)
• Rhodium (chemistry, pharmacology, toxicity)
• Thiocarbamates (chemistry, pharmacology, toxicity)
• Tumor Cells, Cultured