| Abstract | BACKGROUND: We evaluated the effectiveness of intraarterial methotrexate infusion as a primary therapy for oral verrucous carcinoma (VC). METHODS: Fifteen male patients (mean age, 55 years) were included. By using an implantable port-catheter system and a portable pump, methotrexate was continuously infused to the external carotid artery for a mean period of 7.5 days (50 mg/day), followed by weekly bolus of methotrexate (25 mg) via intraarterial route for a mean period of 10 weeks. RESULTS: The tumor regressed dramatically and disappeared completely after treatment within a mean period of 2.5 months. All patients obtained complete remission and recovered without disfigurement. All patients were alive without disease recurrence at a median follow-up of 43 months. The side effects were tolerable. CONCLUSIONS: The results of our treatment modality for oral VC appear to compete favorably with the results of surgical series and even more with those of radiotherapy series. |
| Authors | Chih-Fung Wu, Chung-Ming Chen, Yee-Shyong Shen, I-Yueh Huang, Chung-Ho Chen, Ching-Yi Chen, Tien-Yu Shieh, Maw-Chang Sheen
(Affiliation: Department of Surgery, Faculty of Medicine, College of Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan.)
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| Journal | Head & neck
(Head Neck)
Vol. 30
Issue 5
Pg. 611-7
(May 2008)
ISSN: 1043-3074 United States |
| PMID | 18098309
(Publication Type: Journal Article)
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