The novel phenylester anticancer compounds: Study of a derivative of aspirin (phoshoaspirin).

Abstract

We have synthesized a series of novel phenylester compounds and present our assessment of such a derivative of aspirin, 3-((diethoxyphosphoryloxy)methyl)phenyl 2-acetoxybenzoate, provisionally named phosphoaspirin. We determined its anticancer activity both in vitro and in vivo. Phosphoaspirin inhibited the growth of HT-29 human colon adenocarcinoma cells (IC(50) = 276.6+/-12.3 microM (mean +/- SEM)] through a combined antiproliferative and mainly proapoptotic effect. Phosphoaspirin (100 mg/kg body weight intraperitoneally daily for 21 days) also inhibited the growth of HT-29 tumors grown as xenografts in nude mice. The size of the tumors decreased progressively in the phosphoaspirin treated group, compared to controls, being reduced by 57% (p<0.001) on day 21. Phosphoaspirin achieved this effect by modulating cell kinetics; the proliferation index of cancer cells was reduced by 18.13% compared to controls (p<0.001) and the apoptosis index was increased by 94.6% (p<0.003). There was no apparent toxicity from phosphoaspirin. We conclude that phosphoaspirin is a promising agent for the control of cancer that deserves further evaluation.

• Authors: Basil Rigas, Vasiliki Kozoni
• Journal: International journal of oncology (Int J Oncol) Vol. 32 Issue 1 Pg. 97-100 (Jan 2008) ISSN: 1019-6439 [Print] Greece
• PMID: 18097547 (Publication Type: Journal Article)

Chemical References

• Antineoplastic Agents
• Organophosphates
• phosphoaspirin
• Nitric Oxide
• Aspirin

Topics

• Animals
• Antineoplastic Agents (pharmacology)
• Aspirin (analogs & derivatives, pharmacology)
• HT29 Cells
• Humans
• Mice
• Neoplasm Transplantation
• Nitric Oxide (physiology)
• Organophosphates (pharmacology)
• Transplantation, Heterologous